| エビデンスのレベル | シンボル | 定義 | Wording * |
|---|---|---|---|
| レベル A （高） |
 |
We are very confident that the true effect lies close to that of the estimate of the effect. （真の効果が効果推定値に近いことに大きな確信がある） |
…is effective / has some effect / is not effective / is harmful… |
| レベル B (中) |
 |
We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. （効果推定値に対し中等度の確信がある。つまり、真の効果は効果推定値に近いと考えられるが、大きく異なる可能性も否めない） |
appears to be effective / appears to have some effect / appears not to be effective / appears to be harmful… |
| レベル C (低) |
 |
Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. （効果推定値に対する確信には限界がある。真の効果は効果推定値とは大きく異なるかもしれない） |
may be effective / may have limited effect / may not be effective / may be harmful… |
| レベル D (非常に低) |
 |
We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. （効果推定値に対し、ほとんど確信が持てない。真の効果は、効果推定値とは大きく異なるものと考えられる） |
might possibly/might possibly not ….be effective/have limited effect/be harmful… but the evidence is insufficient** There is insufficient evidence on the effect... *** |
|
* A suitable verb can be used instead of the word “effective”, e.g. “...appears to improve survival”; “...may not prevent exacerbations”. ** “Might possibly be effective/have limited effect/be harmful” can be used when the point estimate suggests clinically meaningful/almost clinically meaningful beneficial or harmful effect. *** This expression is used if no point estimate of the effect is available. | |||